廖晟宇,马儒林,张向辉,王馨平,何欣,郭恒

• 1:石河子大学医学院预防医学系

摘要(Abstract)：

目的：探讨哈萨克族H型高血压与同型半胱氨酸（Hcy）代谢相关基因MTHFR多态性和叶酸的关联，为H型高血压发病机制提供理论依据。方法：应用新疆哈萨克族H型高血压现况调查数据库，采用病例-对照研究，随机选取H型高血压患者100例、单纯高血压患者100例、高Hcy血症患者100例，健康人群100例作为对照组。应用Sanger测序法对所有研究对象的MTHFR基因rs1801133、rs1801131位点进行基因型检测。叶酸采用电化学发光法进行检测。采用χ~2检验进行Hardy-Weinberg平衡检验；应用二分类非条件Logistic回归分析H型高血压与MTHFR基因位点以及叶酸之间的关联。结果：以健康组为对照，高水平叶酸是哈萨克族H型高血压的保护因素(OR=0.33, 95%CI:0.15-0.72),rs1801133-(CT+TT)基因型是危险因素(OR=6.37, 95%CI:2.97-13.68)；高水平叶酸是哈萨克族高Hcy血症的保护因素(OR=0.45, 95%CI:0.23-0.86),rs1801133-(CT+TT)基因型是危险因素(OR=2.92,95%CI:1.52-5.62)。结论：MTHFR基因的rs1801133-T等位基因和rs1801133-(CT+TT)基因型是H型高血压的危险因素；高水平叶酸是H型高血压的保护因素。

关键词(KeyWords)： 哈萨克族;H型高血压;MTHFR基因;叶酸

Abstract:

Keywords:

基金项目(Foundation): 新疆生产建设兵团财政科技计划项目（2021AB030）;; 石河子大学创新发展项目（CXFZ202005）

作者(Author): 廖晟宇,马儒林,张向辉,王馨平,何欣,郭恒

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